View all of Dr. Abel's publications on PubMed

2020 Scientific Reports

  1. Li X, Wu J, Sun X, Wu Q, Li Y, Li K, Zhang Q, Li Y, Abel ED, Chen H. Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury. Stem Cell Reports. 2020 Mar 10;14(3):420-432. doi: 10.1016/j.stemcr.2020.01.008. Epub 2020 Feb 13. PMID: 32059792; PMCID: PMC7066233.
  2. Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal J, Kensler TW, Dell'Italia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Namakkal Soorappan R. Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxid Redox Signal. 2020 Feb 16:10.1089/ars.2019.7808. doi: 10.1089/ars.2019.7808. Epub ahead of print. PMID: 3206489
  3. Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED. Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 Mar 26;5(6):e134920. doi: 10.1172/jci.insight.134920. PMID: 32213702; PMCID: PMC7213803.
  4. Ponce JM, Coen G, Spitler KM, Dragisic N, Martins I, Hinton A Jr, Mungai M, Tadinada SM, Zhang H, Oudit GY, Song LS, Li N, Sicinski P, Strack S, Abel ED, Mitchell C, Hall DD, Grueter CE. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics. J Am Heart Assoc. 2020 Apr 7;9(7):e014366. doi: 10.1161/JAHA.119.014366. Epub 2020 Apr 4. PMID: 32248761.
  5. Badolia R, Ramadurai DKA, Abel ED, Ferrin P, Taleb I, Shankar TS, Thodou Krokidi A, Navankasattusas S, McKellar SH, Yin M, Kfoury AG, Wever-Pinzon O, Fang JC, Selzman CH, Chaudhuri D, Rutter J, Drakos SG. The Role of Non-Glycolytic Glucose Metabolism in Myocardial Recovery upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure. Circulation. 2020 Apr 30. doi: 10.1161/CIRCULATIONAHA.119.044452. Epub ahead of print. PMID: 32351122.
  6. Wende AR, Schell JC, Ha CM, Pepin ME, Khalimonchuk O, Schwertz H, Pereira RO, Brahma MK, Tuinei J, Contreras-Ferrat A, Wang L, Andrizzi CA, Olsen CD, Bradley WE, Dell'Italia LJ, Dillmann WH, Litwin SE, Abel ED. Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction. Diabetes. 2020 May 4:db191057. doi: 10.2337/db19-1057. Epub ahead of print. PMID: 32366681.
  7. Veys K, Fan Z, Ghobrial M, Bouché A, García-Caballero M, Vriens K, Conchinha NV, Seuwen A, Schlegel F, Gorski T, Crabbé M, Gilardoni P, Ardicoglu R, Schaffenrath J, Casteels C, De Smet G, Smolders I, Van Laere K, Abel ED, Fendt SM, Schroeter A, Kalucka J, Cantelmo AR, Wälchli T, Keller A, Carmeliet P, De Bock K. Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity. Circ Res. 2020 May 14. doi: 10.1161/CIRCRESAHA.119.316463. Epub ahead of print. PMID: 32404031.
  8. Ritchie RH, Abel ED. Basic Mechanisms of Diabetic Heart Disease. Circ Res. 2020 May 22;126(11):1501-1525. doi: 10.1161/CIRCRESAHA.120.315913. Epub 2020 May 21. PMID: 32437308.
  9. Contat C, Ancey PB, Zangger N, Sabatino S, Pascual J, Escrig S, Jensen L, Goepfert C, Lanz B, Lepore M, Gruetter R, Rossier A, Berezowska S, Neppl C, Zlobec I, Clerc-Rosset S, Knott GW, Rathmell JC, Abel ED, Meibom A, Meylan E. Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. Elife. 2020 Jun 23;9. pii: e53618. doi: 10.7554/eLife.53618. PubMed PMID: 32571479; PubMed Central PMCID: PMC7311173.
  10. Li B, Lee WC, Song C, Ye L, Abel ED, Long F. Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation. FASEB J. 2020 Jul 6. doi: 10.1096/fj.202000771R. [Epub ahead of print] PubMed PMID: 32627870.
  11. Brahma MK, Ha CM, Pepin ME, Mia S, Sun Z, Chatham JC, Habegger KM, Abel ED, Paterson AJ, Young ME, Wende AR. Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization. J Am Heart Assoc. 2020 Aug 4;9(15):e013039. doi: 10.1161/JAHA.119.013039. Epub 2020 Jul 30. PMID: 32750298.

2019 Scientific Reports 

  1. Swarup A, Samuels IS, Bell BA, Han JYS, Du J, Massenzio E, Abel ED, Boesze-Battaglia K, Peachey NS, Philp NJ. Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells. Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C121-C133. doi: 10.1152/ajpcell.00410.2018. Epub 2018 Nov 21. PubMed PMID: 30462537.
  2. Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 Jan 4;124(1):161-169. doi: 10.1161/CIRCRESAHA.118.314216. PubMed PMID: 30605412.
  3. Kenny HC, Abel ED. Heart Failure in Type 2 Diabetes Mellitus. Circ Res. 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. PubMed PMID: 30605420.
  4. Freemerman AJ, Zhao L, Pingili AK, Teng B, Cozzo AJ, Fuller AM, Johnson AR, Milner JJ, Lim MF, Galanko JA, Beck MA, Bear JE, Rotty JD, Bezavada L, Smallwood HS, Puchowicz MA, Liu J, Locasale JW, Lee DP, Bennett BJ, Abel ED, Rathmell JC, Makowski L. Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1. J Immunol. 2019 Jan 18. pii: ji1800002. doi: 10.4049/jimmunol.1800002. [Epub ahead of print] PubMed PMID: 30659108.
  5. Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel ED. Glucose Metabolism is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes Mellitus. Diabetes. 2019 Feb 14. pii: db180981. doi: 10.2337/db18-0981. [Epub ahead of print] PubMed PMID: 30765335.
  6. Chen H, Ji X, Lee WC, Shi Y, Li B, Abel ED, Jiang D, Huang W, Long F. Increased glycolysis mediates Wnt7b-induced bone formation. FASEB J. 2019 Mar 26:fj201900201RR. doi: 10.1096/fj.201900201RR. [Epub ahead of print] PubMed PMID: 30913395.
  7. Li K, Li M, Li W, Yu H, Sun X, Zhang Q, Li Y, Li X, Li Y, Abel ED, Wu Q, Chen H. Airway epithelial regeneration requires autophagy and glucose metabolism. Cell Death Dis. 2019 Nov 20;10(12):875. doi: 10.1038/s41419-019-2111-2. PubMed PMID: 31748541; PubMed Central PMCID: PMC6868131.

2018 Scientific Reports

  1. Ock S, Lee WS, Kim HM, Park KS, Kim YK, Kook H, Park WJ, Lee TJ, Abel ED, Kim J. Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts. Biochim Biophys Acta. 2018 Jan 31;1864(4 Pt A):1183-1191. doi: 10.1016/j.bbadis.2018.01.022. [Epub ahead of print] PubMed PMID: 29378301.
  2. Swarup A, Bell BA, Du J, Han JYS, Soto J, Abel ED, Bravo-Nuevo A, FitzGerald PG, Peachey NS, Philp NJ. Deletion of GLUT1 in mouse lens epithelium leads to cataract formation. Exp Eye Res. 2018 Mar 28. pii: S0014-4835(17)30668-1. doi: 10.1016/j.exer.2018.03.021. [Epub ahead of print] PubMed PMID: 29604281.
  3. Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med. 2018 Apr 16. doi: 10.1038/s41591-018-0003-0. [Epub ahead of print] PubMed PMID: 29662201.
  4. Zhou G, Wu J, Gu C, Wang B, Abel ED, Cheung AK, Huang Y. Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats. Clin Sci (Lond). 2018 May 30. pii: CS20171659. doi: 10.1042/CS20171659. [Epub ahead of print] PubMed PMID: 29848510.
  5. Zhang J, Abel ED. Effective Metabolic Approaches for the Energy Starved Failing Heart: Bioenergetic Resiliency via Redundancy or Something Else? Circ Res. 2018 Jul 20;123(3):329-331. doi: 10.1161/CIRCRESAHA.118.313308. PubMed PMID: 30026379; PubMed Central PMCID: PMC6055933
  6. Ock S, Ahn J, Lee SH, Kim HM, Kang H, Kim YK, Kook H, Park WJ, Kim S, Kimura S, Jung CK, Shong M, Holzenberger M, Abel ED, Lee TJ, Cho BY, Kim HS, Kim J. Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation. Int J Cancer. 2018 Nov 15;143(10):2458-2469. doi: 10.1002/ijc.31779. Epub 2018 Sep 22. PubMed PMID: 30070361.
  7. Abel ED. MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE. Trans Am Clin Climatol Assoc. 2018;129:266-278. PubMed PMID: 30166722; PubMed Central PMCID: PMC6116613.
  8. Lee SY, Abel ED, Long F. Glucose metabolism induced by Bmp signaling is essential for murine skeletal development. Nat Commun. 2018 Nov 16;9(1):4831. doi: 10.1038/s41467-018-07316-5. PubMed PMID: 30446646.

2017 Scientific Reports

  1. Fidler TP, Middleton E, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED. Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol. 2017 Jun 29. pii: ATVBAHA.117.309184. doi: 10.1161/ATVBAHA.117.309184. [Epub ahead of print] PubMed PMID: 28663252.
  2. Pereira RO, Tadinada SM, Zasadny FM, Oliveira KJ, Pires KMP, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO J. 2017 Jun 12. pii: e201696179. doi: 10.15252/embj.201696179. [Epub ahead of print] PubMed PMID: 28607005.
  3. Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH. DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab. 2017 May 2;25(5):1135-1146.e7. doi: 10.1016/j.cmet.2017.04.008. PubMed PMID: 28467930; PubMed Central PMCID: PMC5485859.
  4. Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H. Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nat Commun. 2017 Jan 24;8:14095. doi: 10.1038/ncomms14095. PubMed PMID: 28117339; PubMed Central PMCID: PMC5286102.
  5. Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 3;135(1):73-88. doi: 10.1161/CIRCULATIONAHA.116.022281. Epub 2016 Nov 4. PubMed PMID: 27815373; PubMed Central PMCID: PMC5302024.
  6. Wellberg EA, Johnson S, Finlay-Schultz J, Lewis AS, Terrell KL, Sartorius CA, Abel ED, Muller WJ, Anderson SM.  The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis. Breast Cancer Research 2017: 18:131. DOI 10.1186/s13058-016-0795-0. PMC:5168867
  7. Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. SWELL1 is a regulator of adipocyte size, insulin signaling and glucose homeostasis, Nature Cell Biology. 2017: 19:504-517. PMC:5415409.
  8. Fidler TP, Rowley JW, Araujo C, Boudreau LH, Marti A, Souvenir R, Dale K, Boilard E, Weyrich AS, Abel ED. Superoxide Dismutase 2 is Dispensable for Platelet Function. 2017. Thrombosis and Haemostasis. 5;117:1859-1867. doi: 10.1160/TH17-03-0174.
  9.  Fidler TP, Campbell RA, Funari T, Dunne N, Angeles EB, Chaudhuri D, Weyrich AS, Abel ED. Deletion of GLUT1 and GLUT3 Reveal Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. 2017: Cell Reports. 20:881-894. PMC:5600478
  10. McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME. Genetic disruption of the cardiomyocyte circadian clock differentially influence insulin-mediated processes in the heart. 2017: J Molecular and Cellular Cardiology. 110:80-95. PMC:5586500
  11. Wende AR, Kim J, Holland WL, Wayment BE, O’Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED. Glucose transporter 4 (GLUT4) deficient hearts develop maladaptive hypertrophy in response to physiologic or pathologic stresses. 2017:  Am J Physiol Heart Circ Physiol. Aug 19:ajpheart.00101.2017. doi: 10.1152/ajpheart.00101.2017. [Epub ahead of print]
  12. Steinhorn B, Sartoretto JL, Romero N, Kalwa H, Abel ED, Michel T. Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxides from NADPH-oxidase isoforms NOX2 and NOX4. 2017: Free Radic Biol Med. 113:16-25. doi: 10.1016/j.freeradbiomed.2017.09.006. [Epub ahead of print]
  13. Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice. Pires KM, Buffolo M, Schaaf C, Symons JD, Cox J, Abel ED, Selzman CH, Boudina S. J Mol Cell Cardiol. 2017. 113:39-50. doi: 10.1016/j.yjmcc.2017.10.001. [Epub ahead of print]
  14. Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Sloan CL, Pereira RO, Lira VA, Spitzer KW, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission. 2017: Circulation Research. In Press.
  15. Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. JCI Insight. 2017 Dec 21;2(24). pii: 96184. doi: 10.1172/jci.insight.96184. [Epub ahead of print] PubMed PMID: 29263294.

2016 Scientific Reports

  1. Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ. Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circ Res. 2016 Mar 24. pii: RES.0000000000000097. [Epub ahead of print]
  2.  Park SY, Rossman MJ, Gifford JR, Bharath LP, Bauersachs J, Richardson RS, Abel ED, Symons JD, Riehle C. Exercise Training Improves Vascular Mitochondrial Function. Am J Physiol Heart Circ Physiol. 2016 Jan 29:ajpheart.00751.2015. doi: 10.1152/ajpheart.00751.2015. [Epub ahead of print]
  3. Ni R, Zheng D, Xiong S, Hill DJ, Sun T, Gardiner RB, Fan GC, Lu Y, Abel ED, Greer PA, Peng T. Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. Diabetes. 2016 Jan;65(1):255-68. doi: 10.2337/db15-0963. Epub 2015 Oct 15.
  4. Ock S, Lee WS, Ahn J, Kim HM, Kang H, Kim HS, Jo D, Abel ED, Lee TJ, Kim J. Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice. Endocrinology. 2016 Jan;157(1):336-45. doi: 10.1210/en.2015-1709. Epub 2015 Oct 15.
  5. Jaishy B, Abel ED. Lipids, Lysosomes and Autophagy. J Lipid Res. 2016 Jun 21. pii: jlr.R067520. [Epub ahead of print] PubMed PMID: 27330054.
  6. Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell Metab. 2016 Apr 12;23(4):649-62. doi: 10.1016/j.cmet.2016.03.008. PubMed PMID: 27076078; PubMed Central PMCID: PMC4832577.
  7. Riehle C, Abel ED. Insulin Signaling and Heart Failure. Circ Res. 2016 Apr 1;118(7):1151-69. doi: 10.1161/CIRCRESAHA.116.306206. Review. PubMed PMID: 27034277; PubMed Central PMCID: PMC4833475.
  8. O’Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson M, Cai W, Kleinridders A, Pereira RO, Hirshman MF, E Abel ED, Accili D, Goodyear LJ, K. Nair3 S, Kahn CR. Interplay Between Insulin/IGF-1 Receptors and FoxO-Mediated Signaling in the Control of Muscle Proteostasis. 2016: Journal of Clinical Investigation. 126:3433-3446. PMC:5004956
  9. Diakos NA, Navankasattusas S, Abel ED, Rutter J, McCreath L, Ferrin P, Park S, Richardson R, Deberardinis R, Cox JE, Kfoury AG, Selzman, CH, Stehlik, J, Fang, JC, Li, DY, Drakos SG. Evidence of glycolysis upregulation and pyruvate mitochondrial oxidation mismatch during mechanical unloading of the failing human heart: implications for cardiac reloading and conditioning. 2016: J American Coll Cardiol, Basic to Translational Science. 2016, 1:432–444. PMC:5422992
  10. Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, Li Z, Abel ED, Migaud ME, Brenner C. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016: 7:12948. doi: 10.1038/ncomms12948. PMC:5062546

2015 Scientific Reports

  1. Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015 Apr;18(4):521-530. doi: 10.1038/nn.3966. Epub 2015 Mar 2
  2. Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED. Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes. Mol Cell Biol. 2015 Mar;35(5):831-46. doi: 10.1128/MCB.01109-14. Epub 2014 Dec 22.
  3. Jaishy B, Zhang Q, Chung HS, Riehle C, Soto J, Jenkins S, Abel P, Cowart LA, Van Eyk JE, Abel ED. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015 Mar;56(3):546-61. doi: 10.1194/jlr.M055152. Epub 2014 Dec 21.
  4. Koentges C, König A, Pfeil K, Hölscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, Abel ED, Bode C, Bugger H Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1. Basic Res Cardiol. 2015 110: 495. doi: 10.1007/s00395-015-0495-4. Epub 2015 May 16
  5. Ilkun O, Wilde N, Tunei J, Pires KM, Zhu Y, Bugger H, Soto J, Wayment B, Olsen C, Litwin SE, Abel ED. Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome. J Mol Cell Cardiol. 2015 May 21. pii: S0022-2828(15)00160-1. doi: 10.1016/j.yjmcc.2015.05.012. [Epub ahead of print] 
  6. Rasmussen TP, Wu Y, Joiner MA, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proc Natl Acad Sci U S A. 2015 Jul 7. pii: 201504705. [Epub ahead of print]
  7. Bharath LP, Ruan T, Li Y, Ravindran A, Wan X, Nhan JK, Walker ML, Deeter L, Goodrich R, Johnson E, Munday D, Mueller R, Kunz D, Jones D, Reese V, Summers SA, Anandh Babu PV, Holland WL, Zhang QJ, Abel ED, Symons JD. Ceramide initiated protein phosphatase 2A activation contributes to arterial dysfunction in vivo. Diabetes. 2015 Aug 7. pii: db150244. [Epub ahead of print]PMID: 26253611
  8. Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC, Fujioka H, Ye F, Rosca MG, Hoppel CL, Schulze PC, Abel ED, Stamler JS, Kelly DP, Jain MK. Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. J Clin Invest. 2015 Aug 4. pii: 79964. doi: 10.1172/JCI79964. [Epub ahead of print]PMID: 26241060
  9. Ping-Chih Ho, Jessica Dauz Bihuniak, Andrew N. Macintyre, Matthew Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, Guoliang Cui, Goran Micevic, Jose C. Perales, Steven H. Kleinstein, E. Dale Abel, Karl L. Insogna, Stefan Feske, Jason W. Locasale, Marcus W. Bosenberg, Jeffrey C. Rathmell, Susan M. Kaech.  Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Aug. doi:10.1016/j.cell.2015.08.012
  10. Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Sep 10;162(6):1217-28. doi: 10.1016/j.cell.2015.08.012. Epub 2015 Aug 27.
  11.  Ni R, Zheng D, Xiong S, Hill DJ, Sun T, Gardiner RB, Fan G-C, Lu Y, Abel ED, Greer PA, Peng T. Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type-1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy. Diabetes. 2015.  In Press.
  12. Ock S, Lee WS, Ahn J, Kim HM, Kang H, Kim H-S, Jo D, Abel ED, Lee TJ, Kim J. Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice. Endocrinology. 2015. In Press.
  13. Noh J, Wende AR, Olsen CD, Kim B, Bevins J, Zhu Y, Zhang QJ, Riehle C, Abel ED.  Phosphoinositide Dependent Protein Kinase 1 is Required for Exercise-induced Cardiac Hypertrophy but not the Associated Mitochondrial Adaptations.  J. Molecular and Cellular Cardiology. 2015: In Press.

2014 Scientific Reports

  1. Parra V, Verdejo HE, Iglewski M, del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jana F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-m-TOR-NFKB-Opa-1 signaling pathway. Diabetes. 2014:63:75-88. PMID:24009260, PMC:3868041
  2. Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A. Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice. Circ Heart Fail. 2014; 7(1):184-93. PMID: 24319095, PMC:390354
  3. Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Riehle C, Abel ED.  Deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure. J Mol Cell Cardiol. 2014; 72C:95-103. PMID:24583251
  4. Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, MUresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo T-H, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Burke GW III, Abel ED, BRosius FC 3rd, Fornoni A. Podocyte-specific GLUT4 deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes. 2014: 63(2):701-14.  PMID:24101677, PMC:3900538
  5. Lopez-Izquierdo A, Pereira R, Wende AR, Punske BB, Abel ED. Tristani-Firouzi M.  The absence of insulin signaling in the heart induces changes in potassium channels expression and ventricular repolarization.  Am J Physiol Heart Circ Physiol. 2014:316:H747-54. PMID: 24375641, PMC:3949065
  6. Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2 adrenergic signaling in hearts. Diabetes. 2014 Mar 27. PMID:24677713
  7. Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 2014; 192(8):3626-36. PMID:24616478, PMC:3984038
  8. Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED. Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function. FASEB J. 2014 Apr 28. PMID:24776744
  9. Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED. Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Mol Cell Biol. 2014 Sep 15;34(18):3450-60. doi: 10.1128/MCB.00426-14. Epub 2014 Jul 7.
  10. Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC.The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 2014 Jul 1;20(1):61-72.

2013 Scientific Reports

  1. Mossalam M, Soto J, Lim CS, Abel ED, Solid phase synthesis of mitochondrial triphenylphosphonium-vitamin E metabolite using a lysine linker for reversal of oxidative stress. PLoS One. 2013;8(1):e53272. doi: 10.1371/journal.pone.0053272. Epub 2013 Jan 14. 
  2. Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED, Mechanistic Target of Rapamycin (Mtor) is Essential for Murine Embryonic Heart Development and Growth. PLoS One. 2013;8(1):e54221. doi: 10.1371/journal.pone.0054221. Epub 2013 Jan 14.
  3. Zhu Y, Pereira RO, O'Neill BT, Riehle C, Ilkun O, Wende AR, Rawlings TA, Zhang YC, Zhang Q, Klip A, Shiojima I, Walsh K, Abel ED. Cardiac PI3K-Akit impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation. Mol Endocrinol. 2013 Jan;27(1):172-84. doi: 10.1210/me.2012-1210. Epub 2012 Nov 30.
  4. Sohn K, Wende AR, Abel ED, Moreno AP, Sachse FB, Punske BB. Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia. Exp Physiol. 2013 Mar;98(3):746-57. doi: 10.1113/expphysiol.2012.070235. Epub 2012 Nov 23.
  5. Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS. Talin 1 has Unique Expression vs. Talin 2 in the Heart and Modifies the Hypertrophic Response to Pressure Overload. J Biol Chem. 2013 Feb 8;288(6):4252-64. doi: 10.1074/jbc.M112.427484. Epub 2012 Dec 24.
  6. Shin J, Lee SH, Kwon MC, Yang DK, Seo HR, Kim J, Kim YY, Im SK, Abel ED, Kim KT, Park WJ, Kong YY. Cardiomyocyte Specific Deletion of Crif1 Causes Mitochondrial Cardiomyopathy in Mice. PLoS One. 2013;8(1):e53577. doi: 10.1371/journal.pone.0053577. Epub 2013 Jan 4.
  7. Shibayama J, Taylor TG, Venable PW, Rhodes NL, Gil RB, Warren M, Wende AR, Abel ED, Cox J, Kenneth W, Spitzer KW, Zaitsev AV. Metabolic Determinants of Electrical Failure in Ex-Vivo Canine Model of Cardiac Arrest: Evidence for the Protective Role of Inorganic Pyrophosphate. PLoS ONE 2013;8(3):e57821. PMID:23520482, PMC:3592894
  8. Bosse JD, Lin HY, Sloan C, Zhang QJ, Abel ED, Pereira TJ, Dolinsky VW, Symons JD, Jalili T. A low carbohydrate-high fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance. Am J Physiol Heart Circ Physiol. 2013;304:H1733-42. PMID:23604708, PMCID:3680768
  9. Zhu Y, Soto J, Anderson B, Riehle C, Zhang YC, Wende AR, Jones D, McClain DA, Abel ED. Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α. Am J Physiol Heart Circ Physiol. 2013;305:H41-51. PMID:23624629
  10. Kannan S. Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. Nrf2 Deficiency Prevents Reductive Stress Induced Hypertrophic Cardiomyopathy. Cardiovascular Research. 2013;100:63-73. PMID:2371402, PMC:3778956
  11. Ock S, Ahn J, Lee SH, Kang H, Offermanns S, Ahn HY, JO YS, Shong M, Cho BY, Jo D, Abel ED, Lee TJ, Park WJ, Lee IK, Kim J. IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter. FASEBJ. 2013;27:4899-4908. PMID:23982142
  12. Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Anderson SM, Abel ED. Inducible Overexpression of GLUT1 Prevents Mitochondrial Dysfunction and Attenuates Structural Remodeling in Pressure Overload but does not Prevent Left Ventricular Dysfunction. Journal of the American Heart Association (JAHA). 2013;2:e000301. PMID:24052497, PMC:3835233
  13. Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina S. Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms. Journal of Molecular and Cellular Cardiology. 2013;64:20-29. PMID:23994159, PMC:3835741
  14. Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CH, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, and Abel ED. Insulin Receptor Substrate Signaling Suppresses Neonatal Autophagy in the Heart. Journal of Clinical Investigation. 2013;123:5319-5333.PMID:24177427, PMC:3859408

2012 Scientific Reports

  1. Troncoso R, Vicencio JM, Parra V, Nemchenko A,Kawashima Y, del Campo A, Toro B, Battiprolu PK, Aranguiz P, Chiong M, Yakar S, Gillette TG, Hill JA, Abel ED, LeRoith D, Lavandero S. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc Res. 2012 Feb 1;93(2):320-9. doi: 10.1093/cvr/cvr321. Epub 2011 Dec 1.
  2. Li Y, Wende AR, Nunthakungwan O, Huang, Y, Hu E, Jin H, Boudina S, Abel ED, Jalili T. Cytosolic, but not mitochondrial, oxidative stress likely contributes to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice. FEBS Journal. 2012. 279:599-611.
  3. Han CY, Umemoto T, Omer M, Den Hartigh LJ, Chiba T, LeBoeuf R, Buller CL, Sweet IR, Pennathur S, Abel ED, Chait A. NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. Journal of Biological Chemistry 2012. 287:10379-93.
  4. Ock S, Ahn J, Lee SH, Park H, Son JW, Oh JG, Yang DK, Lee WS, Kim H-S, Rho J, Oh GT, Abel ED, Park WJ, Min J-K, Kim J. Receptor activator of nuclear factor-?B ligand (RANKL) is a novel inducer of myocardial inflammation. Cardiovascular Research 2012. 94:105-14.
  5. Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Sheldon E. Litwin SE, Weimer BC, Abel ED, Genetic Loss of Insulin Receptors Worsens Cardiac Efficiency in Diabetes. J Mol Cell Cardiol. 2012 May;52(5):1019-26. doi: 10.1016/j.yjmcc.2012.02.001. Epub 2012 Feb 9. 
  6. Marcus RL, Addison O, LaStayo PC, Hungerford R, Wende AR, Hoffman JM, Abel ED, McClain DA. Regional muscle glucose uptake remains elevated 1 week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes. J Endocrinol Invest. 2013 Feb;36(2):111-7. doi: 10.3275/8333. Epub 2012 Apr 5.
  7. Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Dix P, Losee J, Duncan B, Gale D, Kowalski CA, Deeter N, Nichols A, Michole Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra KK, Summers SA, Abel ED, Symons JD. Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. Diabetes. 2012 Jul;61(7):1848-59. doi: 10.2337/db11-1399. Epub 2012 May 14.
  8. Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED. Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity. Endocrinology. 2012 Jun;153(6):2677-88. doi: 10.1210/en.2011-2147. Epub 2012 Apr 17. 
  9. Riehle C, Abel ED, PGC1 proteins and heart failure. Trends Cardiovasc Med. 2012 May;22(4):98-105. doi: 10.1016/j.tcm.2012.07.003. Epub 2012 Aug 29.
  10. Abel ED, O'Shea KM, Ramasamy R. Insulin resistance: metabolic mechanisms and consequences in the heart. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2068-76. doi: 10.1161/ATVBAHA.111.241984.
  11. Ishiwata T, Orosz A, Wang X, Mustafi SB, Pratt GW, Christians ES, Boudina S, Abel ED, Benjamin IJ. HSPB2 Is Dispensable for the Cardiac Hypertrophic Response but Reduces Mitochondrial Energetics following Pressure Overload In Mice. PLoS ONE. 2012. 7(8): e42118. doi:10.1371/journal.pone.0042118
  12. Gounder SS, Kannan S, Devadossa D, Millera CJ, Whitehead K, Odelberg SJ, Firpo MA, Paine R3rd, Hoidal JR, Abel ED, Rajasekaran NS. Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress is Reversible by Moderate Exercise Training. PloS ONE, 2012. 7(9):e45697. doi: 10.1371/journal.pone.0045697.

2011 Scientific Reports

  1. Symons JD, Hu P, Yang Y, Wang X, Zhang QJ, Wende AR, Sloan CS, Sena S, Abel ED, Litwin SE. Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2011: 300:H374-81.
  2. Huang J, Jones D, Luo B, Sanderson M, Soto J, Abel ED, Cooksey RC, McClain DA. Iron overload and diabetes risk: A shift from glucose to fatty acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes. 2011: 60:80-7.
  3. Sloan C, Tuinei J, Nemetz K, Frandsen J, Soto J, Wride N, Sempokuya T, Alegria L, Bugger H, Abel ED, Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric restricted ob/ob mice. Diabetes. 2011: 60:1424-34.
  4. Pound KM, Arteaga GM, Fasano M, Wilder T, Fischer SK, Warren CM, Wende AR, Farjah M, Abel ED, Solaro RJ, Lewandowski ED. Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia. J Mol Cell Cardiol. 2011: 51:236-43.
  5. Poussin C, Ibberson M, Hall D, Ding J, Soto J, Abel ED, Thorens B. Oxidative phosphorylation flexibility in the liver of mice resistant to high fat diet-induced hepatic steatosis. Diabetes. 2011: 60:2216-24.
  6. Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moura AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED, PGC-1ß Deficiency Accelerates the Transition to Heart Failure in Pressure Overload Hypertrophy. Circulation Research. 2011: 109:783-93
  7. Li Y, Ma J, Zhu H, Singh M, Hill D, Greer PA, Arnold M, Abel ED, Peng T. Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type-I diabetes. Diabetes 2011: 60:2985-94.
  8. Sohn K, Sachse FB, Moreno AP, Ershler PR, Wende AR, Abel ED,Punske BB. The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts. IEEE Transactions on Biomedical Engineering. 2011: 58:3175-83.
  9. Young CD, Lewis AS, Rudolph MC, Ruehle MD, Jackman MR, Yun UJ, Ilkun O, Pereira R, Abel ED, Anderson SM. Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo. PLoS One. 2011: 6(8):e23205.
  10. Ock S. Lee SH, Ahn J, Lee TJ, Cho C-H, Abel ED, Kimura S, Kim J. Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function. Endocrine Journal. 2011. 58:1013-9.

2010 Scientific Reports

  1. Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Molecular and Cellular Biology, 2010: 30:1341-56.
  2. Griesel BA, Weems J, Russell RA, Abel ED, Humphries K, Olson AL. Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through LXR signaling. Diabetes 2010: 59:800-7.
  3. Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M 1, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED, Komuro I. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload. J. Clin Invest. 2010: 120:1506-14.
  4. Cooksey RC, Jones D, Gabrielsen S, Huang J, Simcox JA, Luo B, Soesanto YA, Rienhoff H, Abel ED, McClain DA. Dietary iron restriction or iron chelation protect from diabetes and loss of beta cell function in the obese (ob/ob lep-/-) mouse. Am J Physiol Endocrinol Metab. 2010: 298:E1236-43.
  5. Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED, Loss of Bradykinin Signaling Does Not Accelerate the Development of Cardiac Dysfunction in Type 1 Diabetic Akita Mice. Endocrinology. 2010: 151(8): 3536-42.
  6. Banke NH, Wende AR, Leone TC, O’Donnell JM, Abel ED, Kelly DP, Lewandowski ED. Preferential Oxidation of Triacylglyceride-Derived Fatty Acids in Heart is Augmented by the Nuclear Receptor PPAR?. Circulation Research. 2010. 107(2):233-41.
  7. O'Grady SP, Wende AR, Remien CH, Valenzuela LO, Enright LE, Chesson LA, Abel ED, Cerling TE, Ehleringer JR. Aberrant water homeostasis detected by stable isotope analysis. PLoS ONE 2010: 5(7): e11699.
  8. Son N-H, Yu S, Tuinei J, Arai K, Hamai H, Homma S, Shulman GI, Abel ED, Goldberg IJ. PPAR-gamma-induced cardiolipotoxicity is ameliorated by PPAR-alpha deficiency despite greater fatty acid oxidation in mice. J. Clin Invest. 2010: 120:3443-54.
  9. Fang X, Palanivel R, Cresser J, Schram K, Ganguly R, Thong FS, Tuinei J, Xu A, Abel ED, Sweeney G. An APPL1-AMPK Signaling Axis Mediates Beneficial Metabolic Effects of Adiponectin in the Heart. Am J Physiol Endocrinol Metab. 2010: 299(5):E721-9.
  10. Tanner JM, Kearns DT, Kim BJ, Sloan C, Zhanjun Jia Z, Yang T, Abel ED, Symons JD. Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese vs. lean mice. Exp Biol Med (Maywood). 2010:235:1489-97.

2009 Scientific Reports

  1. Boudina S, Bugger H, Sena S, O'Neill B T, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald HA, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BC, Abel ED, Contribution of impaired insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation 2009: 119:1272-1283.
  2. Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED, Mechanisms for increased myocardial fatty acid utilization following short-term high fat feeding. Cardiovascular Research 2009: 82:351-360.
  3. Sena S, Hu P, Zhang D, Wang X, Wayment B, Olsen C, Avelar E, Abel ED, Litwin SE. Impaired Insulin Signaling Accelerates Cardiac Mitochondrial Dysfunction After Myocardial Infarction. Journal of Molecular and Cellular Cardiology. 2009: 46:910-918.
  4. Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang Q-J, Gale D,Wilson LJ, Abel ED, Contribution of insulin and Akt1 signaling to eNOS in the regulation of endothelial function and blood pressure. Circulation Research. 2009:104:1085-1094.
  5. Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel ED, Brownell AL, and Kandror KV. Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. Journal of Neuroscience. 2009: 29:5193-5201.
  6. Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK, Aguilera G, Abel ED, Chung JH. The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology. 2009: 150:2153-21607.
  7. Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD. Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: Role of vascular signaling kinases. J Physiol. 2009 587:3911-20.
  8. Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel ED, Tissue-Specific Remodeling of the Mitochondrial Proteome in Type 1 Diabetic Akita Mice. Diabetes. 2009 58:1986-97.
  9. Soesanto W, Lin H, Hu E, Lefler S, Litwin SE, Sena S, Abel ED, Symons JD, Jalili T. mTOR is a critical regulator of cardiac hypertrophy in Spontaneously Hypertensive Rats. Hypertension. 2009: 54:1321-1327.
  10. Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel ED, Komuro I. Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. J Mol Cell Cardiol. 2009: 47:664-675.
  11. Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai O, Abel ED, Kulkarni RN. Insulin signaling regulates mitochondrial function in pancreatic b-cells. PLoS ONE 2009: 4(11): e7983.

2008 Scientific Reports

  1. Bray MS, Shaw CA, Moore MW, Garcia RA, Zanquetta MM, Durgan DJ, Jeong WJ, Tsai JY, Bugger H, Zhang D, Rohrwasser A, Rennison JH, Dyck JR, Litwin SE, Hardin PE, Chow CW, Chandler MP, Abel ED, Young ME. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism and gene expression. 2008: Am J Physiol Heart Circ Physiol. 294(2): H1036-47.
  2. Yin Z, Jones G, Towns WH, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS. Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. 2008: Circulation. 117:1414-22.
  3. Amiott EA, Lott P, Soto J, Kang PB, M.D McCaffery JM, DiMauro S, Abel ED, Flanigan KM, Lawson VH, Shaw JM. Mitochondrial Fusion and Function in Charcot-Marie-Tooth Type 2AFibroblasts with Mitofusin 2 Mutations. Experimental Neurology, 2008. 211:115-27.
  4. Jouihan HA, Cobine PA, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA. Insulin deficiency associated with decreased mitochondrial function and abnormal metal distribution in a mouse model of hemochromatosis is reversed by manganese supplementation. Molecular Medicine. 2008 14:98-108.
  5. Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel ED, Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts. 2008: Endocrinology. 149:4043-4050.
  6. Fang C, Gu J, Xie F, Behr M, Yang W, Abel ED, Ding X. Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated cardiac toxicity. 2008: Drug Metab Dispos. 36:1722-1728.
  7. Lehman JJ, Boudina S, Banke NH, Sambandam N Phd, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP. The Transcriptional Coactivator PGC-1{alpha} is Essential for Maximal and Efficient Cardiac Mitochondrial Fatty Acid Oxidation and Lipid Homeostasis. 2008: Am J Physiol Heart Circ Physiol. 295:H185-196.
  8. Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. 2008: J Lipid Res. 49:2101-2112.
  9. Augustus AS, Buchanan J, Addya S, Rengo G, Pestell R, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. Substrate uptake and metabolism are preserved in hypertrophic Caveolin-3 Knockout Hearts. Am J Physiol Heart Circ Physiol. 2008: 295:H657-666.
  10. Mossalam M, Jeong J-H, Abel ED, Kim SW, Kim Y-H. Reversal of oxidative stress in endothelial cells by controlled release of adiponectin. Journal of Controlled Release. 2008: 130: 234-237.
  11. Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED, Type 1 diabetic Akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes. 2008 57:2924-2932.
  12. Augustus AS, Buchanan J, Gutman E, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism. Cell Cycle. 2008 7:2509-2518.
  13. Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED, IGF-1 Receptor signaling is required for exercise-induced cardiac hypertrophy. Molecular Endocrinology. 2008: 22:2531-2543.

2007 Scientific Reports

  1. Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Makela TP, Schneider MD. Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metabolism. 2007: 5:129-142.
  2. Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED, Mitochondrial energetics in the heart in obesity related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins. 2007: Diabetes 56(10):2457-66.
  3. Sena S, Rasmussen IR, Wende AR, McQueen AP, Theobald HA, Wilde N, Pereira RO, Litwin SE, Berger JP, Abel ED, Cardiac Hypertrophy Caused by Peroxisome Proliferator Activated Receptor-Gamma Agonist Treatment Occurs Independently of Changes in Myocardial Insulin Signaling. 2007: Endocrinology 148:6047-53.
  4. Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J PAS kinase is required for normal cellular energy balance. 2007: Proc Natl Acad Sci U S A 104(39):15466-71.
  5. Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor R, Rajasekaran NS, Gottlieb RA, Wawrousek E, Abel ED, Bolli R CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. 2007 Am J Physiol Heart Circ Physiol 293(5):H3201-3209.
  6. O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED, A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. 2007: Cell Metabolism. 6(4):294-306.

2006 Scientific Reports

  1. Augustus AS, Buchanan J, Park TS, Hirata K, Noh HL, Sun J, Homma S, D'armiento J, Abel ED, Goldberg IJ. Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. 2006. J Biol Chem. 281:8716-8723.
  2. Durgan DJ, Smith JK, Hotze MA, Egbejimi O, Cuthbert KD, Zaha VG, Dyck JR, Abel ED, Young ME. Distinct Transcriptional Regulation of Long-Chain Acyl-CoA Synthetase Isoforms and Cytosolic Thioesterase 1 in the Rodent Heart by Fatty Acids and Insulin. 2006. Am J Physiol Heart Circ Physiol. 290:H2480-2497.
  3. Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, Abel ED, Pu W, Izumo S, Jay, P.Y. Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. 2006. J. Cardiac Failure. 12:392-398.
  4. Lelliot CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Bloun M, Lopez M, Meirhaeghe A, Bohlooly M, Storlien L, Strömstedt M, Snaith M, Ore M, Abel ED, Cannon B, Vidal-Puig A. Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function and cardiac performance. 2006. PLoS Biology. 4(11):e369.

2005 Scientific Reports

  1. Rui T, Feng Q, Lei M, Peng T, Zhang J, Xu M, Abel ED, Xenocostas A, Kvietys PR. Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion in vitro and in vivo: role of AP-1. 2005. Cardiovascular Research. 65:719-727.
  2. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. PGC-1a Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis. 2005. PLOS Biology 3(4)e101.
  3. Durgan DJ, Hotze MA, Tomlin TM, Egbejimi O, Gravelelau G, Abel ED, Shaw CA, Bray MS, Hardin PE, Young ME. The intrinsic circadian clock within the cardiomyocyte. 2005 American Journal of Physiology. 289:H1530-1541.
  4. Graveleau C, Zaha VG, Mohajer A, Banerjee RR, Dudley-Rucker N, Steppan CM, Rajala MW, Scherer PE, Ahima RS, Scherer PS, Lazar MA, Abel ED, Mouse and human resistin impair glucose transport in primary mouse cardiomyocytes and oligomerization is required for this biological action. 2005. J. Biol Chem. 280:31679-31685.
  5. Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel ED, Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.2005. Endocrinology146:5341-5349.
  6. McQueen AP, Zhang D, Hu P, Swenson L, Yang Y, Zaha VG, Hoffman JL, Yun UJ, Chakrabarti G, Wang Z, Albertine KH, Abel ED,, Litwin SE*. Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density. 2005. J. Molecular and Cellular Cardiology.39:882-892 (* Corresponding authors).
  7. Boudina S, Sena S, O’Neill BT, Tathireddy P, Young ME, Abel ED, Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impairs myocardial energetics in obesity. 2005. Circulation.112:2686-2695.

2004 Scientific Reports

  1. Shimoni Y, Chuang M, Abel ED, Severson DL. Gender dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice. 2004: J. Physiol. 555(2) : 345-354.
  2. Hayashi M, Kim S-W, Imanaka-Yoshida K, Yoshida T, Abel ED, Elicieri B, Yang Y, Ulevich RJ, Lee J-D. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. 2004: Journal of Clinical Investigation. 113:1138-1148.
  3. Mazumder PK, O’Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S, Abel ED, Impaired Cardiac Efficiency and Increased Fatty Acid Oxidation in Insulin Resistant ob/ob mouse hearts. 2004: Diabetes. 53: 2366-2374.
  4. Abel ED, Graveleau C, Betuing S, Pham M, Reay PA, Kandror V, Kupriyanova T, Xu Z, Kandror KV. Regulation of IRAP expression and targeting in the insulin responsive vesicle compartment of GLUT4 deficient cardiomyocytes. 2004. Molecular Endocrinology. 18:2491-2501.
  5. Stavinoha MA, RaySpellicy JW, Essop MF, Graveleau C, Abel ED, Hart-Sailors ML, Mersmann HJ, Bray MS, Young ME. Evidence for mitochondrial thioesterase 1 as a peroxisome proliferators-activated receptor alpha regulated gene in cardiac and skeletal muscle. 2004. American Journal of Physiology. 287 (5): E888-895.
  6. Punske BB, Rossi S, Erschler P, Rasmussen I, Abel ED, Optical mapping of propagation changes induced by elevated extracellular potassium ion concentration in genetically altered mouse hearts. 2004. Journal of Electrocardiology. 37: Suppl. 128-134.

2000 - 2003 Scientific Reports

  1. Pazos-Moura C, Abel ED,, Boers M-E, Moura E, Hampton TG, Wang J, Morgan JP, Wondisford FE. Cardiac dysfunction caused by myocardial-specific expression of a mutant thyroid hormone receptor. Circulation Research 2000; 86:700-706 (* Co-first Author).
  2. Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance Nature Medicine 2000; 6:924-928.
  3. Pachucki J, Hopkins J, Peeters R, Tu H, Carvalho S, Kaulbach H, Abel ED, Wondisford FE, Ingwall J, Larsen PR. Type 2 iodothyronine deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. Endocrinology : 2001;14213-20.
  4. Abel ED, Peroni O, Kim JK, Kim Y-B, Boss O, Hadro E, Minneman T, Shulman GI, Kahn BB. Adipose selective targeting of the GLUT4 Gene impairs insulin action in muscle and liver. Nature 2001; 409:729-733.
  5. Hashimoto K, Curty FH, Borges PP, Lee CH, Abel ED, Elmquist JK, Lawitts J, Cohen RN, Wondisford FE. An unliganded thyroid hormone receptor causes severe neurological dysfunction Proc. of the Natl. Acad.Sci.98:2001;3998-4003.
  6. Abel ED, Ahima RS, Boers M-E, Elmquist JK, Wondisford FE. Critical role for thyroid hormone receptor ß2 in the regulation of TRH neurons in the paraventricular hypothalamus. Journal of Clinical Investigation 107;2001; 1017 1023.
  7. Tian R, Abel ED, The responses of GLUT4 deficient hearts to ischemia underscore the importance of glycolysis. Circulation 2001; 103:2961-2966.
  8. Belke DD, Betuing S, Tuttle MJ, Graveleau C, Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin SE, Taegtmeyer H, Severson D, Kahn CR, Abel ED, Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. Journal of Clinical Investigation 2002; 109: 629-639.
  9. Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, Kahn CR, Abel ED, Walsh K. Akt mediates postnatal cardiac growth in response to insulin and nutritional status. Journal of Biological Chemistry. 2002; 277: 37670-37677.
  10. Hu P, Zhang D, Swenson L, Chakrabarti G, Abel ED, Litwin SE. Minimally invasive aortic banding in mice: Effects of altered cardiomyocyte insulin signaling during pressure-overload . American Journal of Physiology.2003; 285(3): H1261-1269.
  11. Abel ED, Moura EG, Ahima RS, Pazos-Moura CC, Campos-Barros A, Boers ME, Kaulbach H, Forrest D, Wondisford FE. Dominant inhibition of thyroid hormone action selectively in the pituitary of TR-ß null mice abolishes the regulation of thyrotropin by thyroid hormone.2003; Molecular Endocrinology. 17(9): 1767-1776